![]() Īlginate is composed of α- L-guluronic acid (G- blocks) and β-D-mannuronic acid (M- blocks) linked by 1 → 4 glycosidic bonds. Biopolymers exhibit interesting properties that make them suitable for developing wound dressings with the aforementioned features of an ideal wound dressing, and among them is sodium alginate (SA), a brown seaweed-derived polysaccharide. An ideal wound dressing should be non-toxic, protect against bacterial invasion and the external environment, be biocompatible, retain a moist environment, be biodegradable, stimulate cell proliferation and migration and induce rapid wound healing. Over the years, different wound dressings have been developed to accelerate the wound healing process. Therefore, it is of great importance to take good care of wounds using appropriate wound dressings irrespective of their size to avoid further complications. These factors not only delay the wound healing process but also result in a wound becoming chronic. haemophilia, diabetes, obesity, cancer, etc.). Several limitations antagonize the wound healing process, such as alcohol, bacterial infection, old age, using inappropriate wound dressings and health conditions ( i.e. ![]() Acute wounds heal within a limited time of 1–12 weeks, whereas chronic wounds exceed the predicted period. The process of wound healing can be classified based on the type of wound, i.e. keratinocytes, immune, myoblast, endothelial, fibroblast, etc.) that promote the wound healing process. Wound healing is a complex process comprising various pathways and the involvement of different cell types ( i.e. The wound healing capability of these formulations makes them potential wound dressings for treating bleeding and infected wounds. Their antibacterial and blood clotting potential was significant compared to the control. The in vitro wound healing studies of the wound dressings revealed a wound closure of 99% on day 3. The gel formulations displayed pH, spreadability and viscosity in the range of 6.8–7.2, 5.4–10.1 cm and viscosity (3444–1260 cp) after 120 s, respectively. The Fourier transform infrared spectroscopy revealed the absence of a chemical interaction between the iron nanoparticles, tranexamic acid, essential oils and the gel matrix. X-ray diffraction (XRD) and scanning electron microscope (SEM) confirmed the successful formation of Fe 3O 4 nanoparticles. Carbopol was used as a gelling agent and as a surfactant to disperse the EO. Alginate-based topical gels loaded with 2 mL essential oils (eucalyptus, lavender and rosemary oil) in combination with 30 mg magnetite (Fe 3O 4) nanoparticles and 70 mg tranexamic acid were prepared. ![]() Wound management is a key feature in saving people’s lives, and regardless of the wound size, using appropriate wound dressing is crucial. ![]()
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